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Expand Solubility (25C) In vitro dmso 26 mg/mL (199.87 mM) Water Insoluble Ethanol Insoluble In vivo add solvents to the product individually and in order: saline (warming) For best results, use promptly after mixing. 10mg/mL * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. Chemical Information Download Fluorouracil (5-Fluoracil, 5-FU) sdf molecular weight 130.08 Formula C4H3FN2O2 cas. 51-21-8 Storage 3 years -20C powder 2 years -80C in solvent Synonyms nsc 19893 bio calculators Molarity calculator Mass Concentration Volume molecular weight pgngμgmggkg fMpMnMμMmMM nLμLmll clinical Trial Information (data from http clinicaltrials. Gov, updated on ) nct number Recruitment Conditions Sponsor/Collaborators Start Date Phases nct01928290 Recruiting Stomach neoplasmsEsophageal neoplasms Washington University School of Medicine november 8, 2013 Phase 2 nct00193882 Completed Esophagus Cancer Trans-Tasman Radiation Oncology Group (trog)National health and Medical Research council, australiacanadian Cancer Trials Group.
Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments. Handling Instructions Tel: Ext:3 If you have any other enquiries, please leave a message. Indicates a required field * Name: * e-mail: Phone: * Comments: Frequently Asked questions question 1: I was wondering if the product s1209 (5-fluorouracil) is suitable to inject into mice? Answer: S1209 is suitable to inject (I.P.) into mice as indicating in this paper:. Related dna/rna synthesis Products Tags: buy fluorouracil (5-Fluoracil, 5-FU) Fluorouracil (5-Fluoracil, 5-FU) supplier purchase Fluorouracil (5-Fluoracil, 5-FU) Fluorouracil (5-Fluoracil, 5-FU) cost Fluorouracil (5-Fluoracil, 5-FU) manufacturer order Fluorouracil (5-Fluoracil, 5-FU) Fluorouracil (5-Fluoracil, 5-FU) distributor.
Rna and protein synthesis
Weekly (Only for Reference) References 1 great Longley db,. Nat rev cancer, 2003, 3(5 330-338. 2 Qin l,. Biochem biophys Res Commun, 2008, 371(3 531-535. 3 Shi x,. Oncology, 2002, 62(4 354-362. J biol Chem, 1995, 270(32. 5 Van laar ja,. Cancer Chemother Pharmacol, 1996, 39(1-2 79-89.
Click to view More cell Line Experimental Data In vivo adrucil is widely used in the treatment of a range of cancers, including colorectal and breast cancers. 1 100mg/kg Adrucil significantly suppresses tumor english growth of murine colon carcinomas Colon 38 with tumor-doubling time (td growth-delay factor (gdf and T/C.5 days,.4, and. 5 Protocol Cell Research: 4 Expand Cell lines: Human colon carcinoma cell line ht-29 Concentrations: 25 μm incubation Time: 7 days Method: Growth inhibition is measured after treatment of cells with Adrucil for 7 days in 96-well plates (4000 ht-29 cells/well in rpmi 1640 medium. At the end of incubation, cells are rinsed three times with phosphate-buffered saline (pH.4 fixed with 10 trichloroacetic acid for 60 min at 4, washed five times with deionized water, and stained with.4 sulforhoda-mine b solution for 15 min at room temperature. Unstained sulforhodamine b is removed by rinsing with 1 glacial acetic acid. Afterwards, stained cell proteins are dried and dissolved with 10 mM Tris-HCl. The optical density value is measured using a detector at 540 nm wavelength. (Only for Reference) Animal Research: 5 Expand Animal Models: Murine colon carcinomas Colon 38 Formulation: pbs dosages: 100 mg/kg Administration:.
into dna, leading to dna strand breaks and cell death. The pro-apoptosis effects of Adrucil may be related to its activation of tumor suppressor p53. Loss of p53 function reduces cellular sensitivity to Adrucil. 1, adrucil is able to inhibit the survival and induce apoptosis of a board range of cancer cells. Adrucil suppresses viabilities of the nasopharyngeal carcinoma cell line cne2 and hone1 2, pancreatic cancer cell lines Capan-1 3, and human colon carcinoma cell line ht-29 4 with IC50 of 9 μg/mL, 3 μg/mL,.22 μm,.5 μm, respectively. Cell Data, cell Lines, assay type, concentration. Incubation Time, formulation, activity description, pmid, mCF-7. M1y1VI1ODl3MUe2 ht-29 nyico1vpzmeohlCpc m4XDdWleptb-iek1JO69y:vTB? M1LGTlI1ODl3MUe2 nci-h292 nvnyzbkpzmeohlCpc ngnQN3nkszvypjcyoudpxGdxbvy nxxxc5hOjryouwxoy.
EdU staining of rbe cells treated with osi-027 (6.25 μM) and/or 5-fu (6.25 μg/mL) was performed by using Click-it edU Imaging Kit. The percentages of EdU-positive cells have been provided in the right panel. Eur rev friendship med Pharmacol Sci, 2016, 20(9 1699-706. Purity quality control, choose selective dna/rna synthesis Inhibitors. Biological Activity, description, fluorouracil (5-Fluoracil, 5-FU) is a dna/rna synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Targets, thymidylate synthase 1 (Tumor cells in vitro. Adrucil is an analogue of uracil with a fluorine atom at the c-5 position in place of hydrogen. It rapidly enters the cell using the same facilitated transport mechanism as uracil. Adrucil is converted intracellularly to several active metabolites: fluorodeoxyuridine monophosphate (Fdump fluorodeoxyuridine triphosphate (FdUTP) and fluorouridine triphosphate (futp).
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Fluorouracil (5-Fluoracil, 5-FU) dna/rna synthesis inhibitor read reviews product Use citations. S1209, synonyms : nsc 19893, molecular weight(mw 130.08, fluorouracil (5-Fluoracil, 5-FU) is a dna/rna synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) lab in tumor cells. Publications 2, customer reviews, dna-pkcs suppression mediated ros production and gsh content in HepG2 cells exposed to cddp and 5-Fu. A dna-pkcs inhibition promoted ros production in HepG2 cells treated with indicated concentrations of cddp and 5-Fu. Dcfh-da fluorescent analysis was performed to assess the ros level. Data presented were mean? Sd of three independent experiments. Mol Cell biochem 2014.1007/s. Fluorouracil (5-Fluoracil, 5-FU) purchased from Selleck.